Wayne Rooney ended his eight-game Premier League scoring drought with a 2-0 victory against a dogged Sunderland.
West Ham United have agreed to sell their ground at Upton Park to London developer Galliard Group once they have moved to the Olympic Stadium in 2016, the club announced on Monday.
Arsenal held on to top spot with a 2-1 win at Swansea in the Premier League on Saturday after Tottenham drew with Chelsea and both Manchester clubs suffered shock defeats that left them trailing London's big three.
Romelu Lukaku extended his impressive FA Cup scoring record by netting twice in Manchester United's 2-0 win at Huddersfield Town to earn Jose Mourinho's side a quarter-final tie at home to Brighton & Hove Albion.
Chelsea are 10 points clear at top of the English Premier League championship table.
Liverpool had won each of their previous four home leagues games in which they conceded first and 12 minutes later they had turned another match on its head as Roberto Firmino's trickery set up Mane to give the hosts the lead at the second attempt.
Chelsea manager Jose Mourinho should have apologised to former team doctor Eva Carneiro for his criticism of her, Football Association chairman Greg Dyke has said.
Headers by Romelu Lukaku and Nemanja Matic earned Manchester United an unconvincing 2-0 victory over Brighton and Hove Albion in a low-key FA Cup quarter-final played in freezing conditions on Saturday.
Leaders Chelsea stretched their Premier League winning run to a club record-equalling 11 as Diego Costa's header shortly before halftime secured a 1-0 victory at London rivals Crystal Palace on Saturday.
Following is a match by match look at the English Premier League's weekend fixtures:
West Ham United are hoping Andy Carroll's productive double-act with Kevin Nolan will not be derailed by a three-match ban as the Premier League strugglers look to ease their way out of relegation trouble.
Sanchez, 28, is currently in the final year of his contract. He has been linked with a move to Paris St Germain in the current transfer window.
Chelsea's Jose Mourinho, who hoped to celebrate his new contract with victory at an expectant Stamford Bridge, ended up grateful his team did not become the first Premier League champions to start their title defence with a defeat.
Chelsea banking on other big strikers with Costa still doubtful
Ivory Coast midfielder Yaya Toure will not play for Manchester City again until the Premier League club receive an apology for comments made by his agent, manager Pep Guardiola said on Tuesday. "He must apologise. If he doesn't, he won't play," Guardiola told reporters. The 33-year-old player's agent Dimitri Seluk, who had said Toure felt "humiliated" after being left out of City's Champions League squad, hit back in similarly uncompromising fashion.
Seventh-placed Liverpool, who have 14 points from nine matches, travel to a Newcastle side buoyed by their League Cup victory over Manchester City.
Nigerian international Odion Ighalo scored twice as a buoyant Watford won 3-0 at home to Liverpool to consolidate seventh position in the Premier League, only one point behind the top four.
Several Manchester United players are in the 'red zone' according to manager Louis van Gaal as he weighs up his options for Saturday's FA Cup third round tie at home to Sheffield United. A hectic holiday programme, including four games in 15 days, has taken its toll on United's squad and Van Gaal fears that many of his over-stretched players risk injury or burnout. Defender Phil Jones is ruled out through injury while winger Ashley Young might not be risked with United set to face a Premier League clash at Newcastle United three days after playing third tier Sheffield United.
Burnley reached the Europa League third qualifying round with a 3-1 win over Aberdeen after extra time at Turf Moor on Thursday but now face another tough battle to increase their squad size.
Chelsea made light of striker Diego Costa's absence to extend their lead at the top of the Premier League to seven points with a 3-0 win at champions Leicester City.
Liverpool cranked up the pressure on West Ham United manager Slaven Bilic with a 4-1 victory at the London Stadium, while Burnley's remarkable start to the Premier League season continued thanks to a 1-0 victory at Southampton on Saturday.
Chelsea and former manager Jose Mourinho have reached an undisclosed settlement with former team doctor Eva Carneiro at an employment tribunal in London, the Premier League club said on Tuesday.
Eva Carneiro set to lose place on bench after Mourinho criticism
Struggling Premier League champions Chelsea have the quality to climb back up the table under interim manager Guus Hiddink, goalkeeper Thibaut Courtois has said.
It was not a day for FA Cup romantics as Manchester United scrambled past Sheffield United and minor league Eastleigh came within a whisker of causing the third round's only genuine shock.
The visitors got off to the perfect start when a mix up at the back saw Riyad Mahrez square for Jamie Vardy to tap into an open goal in front of the Kop in the third minute. Liverpool looked for an immediate riposte, but Salah missed two gilt-edged opportunities before Sadio Mane saw an effort disallowed for offside as Juergen Klopp's men grew frustrated.
City are 18 points clear of second-placed Liverpool after beating Chelsea 1-0 at the Etihad Stadium on Sunday and need just four wins from their final nine games to be sure of the title.
"Harry Kane, he's one of our own," Tottenham Hotspur supporters sing in praise of the 21 year-old striker from Chingford, the London suburb where David Beckham learnt his football.
Leicester's EPL title credentials on show against champions Chelsea.
With just four matches remaining, Leicester City manager Claudio Ranieri finally acknowledged the obvious and said his unsung side were fighting for the Premier League title and could win it.
Manchester United stretched their unbeaten run to 11 games in all competitions after Daley Blind, in-form striker Zlatan Ibrahimovic and substitute Henrik Mkhitaryan gave them a 3-1 home win over Sunderland on Monday. Left back Blind fired United ahead with a crisp 39th-minute shot after Ibrahimovic teed him up perfectly. The towering Swede doubled the lead with a clinical 82nd-minute finish for his 17th goal of the season. Fit-again Mkhitaryan put the icing on the cake with a spectacular backheel effort after a sharp Ibrahimovic cross from the right, although television replays suggested the Armenian was marginally offside. Striker Fabio Borini gave Sunderland fans something to cheer with a dipping late volley.
Cristiano Ronaldo shows no signs of flagging as he approaches his mid-30s but there are plenty of other worries for a team with an ageing central defence and a number of players struggling for form.
Tottenham Hotspur's Harry Kane pounced on a piece of comical defending to secure a 1-0 win over Sunderland in the Premier League on Sunday although he was later wheeled away on a stretcher after suffering an ankle injury.
News of all that's transpired on and off the football field
Philippe Coutinho scored twice as Liverpool recovered from an early deficit to beat struggling Premier League champions Chelsea 3-1 at Stamford Bridge on Saturday and pile more pressure on Blues manager Jose Mourinho.
Former Manchester United striker Ole Gunnar Solskjaer was named the new manager of English Premier League strugglers Cardiff City on Thursday.
Liverpool were sent spinning to a 2-0 defeat at promoted Burnley in the English Premier League on Saturday while Chelsea came from behind to win 2-1 at Watford thanks to late goals from Michy Batshuayi and Diego Costa.
How quickly affections can switch in soccer. Where once they would serenade coach Jose Mourinho at Stamford Bridge with an operatic flourish, now Chelsea fans have fallen headlong for another man driving them inexorably to the Premier League title.
Aaron Ramsey scored a hat-trick on Saturday as Arsenal thrashed Everton 5-1 in the Premier League at the Emirates with a display of free-flowing football that the Gunners have sorely lacked away from home this season.
A match by match look at this weekend's English Premier League fixtures.